Title: Applications of neural microsystems (P-ITBIO-0042)
Credit value: 3
Category of the subject: optional for students attending Infobionics Engineering Msc at PPCU
Subject owner: Dr. Zoltan Fekete
Teachers involved: Dr. Anita Pongrácz, Dr. Richárd Fiáth, Anita Zátonyi, Ágnes Szabó, Ágoston Csaba Horváth


Description: A course provides comprehensive insight into the interdisciplinary field of neural microsensors and actuators relying on the recent advances in both material- and neuroscience. Operation principles, technological challanges will be addressed through real applications. Main topics included in the lectures:

 1.  History of microscale implants for central and peripheral nervous system research (pdf)

2. Fundamental technological background (pdf)

3. Introduction into the material selection in terms of functionality, processing and biocompatibility (pdf)

4. Recording of neural activity with microelectrode arrays, sensor architectures (pdf)

5. Materials, technology and applications of flexible soft implants, microECoGs and peripheral nerve stimulators  (pdf)

6. Multimodal sensor/stimulator arrays relying on integrated signal processing units (pdf)

7. Integrated drug delivery solutions in microelectrode arrays (pdf)

8. Optogenetics and challanges in optoelectronic microsystem design (pdf)

9. Thermogenetics and implantable microsystems for infrared neural stimulation (pdf)

10. Infuence of physical and chemical properties of microimplant surfaces on long-term stability (pdf)

11. Mechanical interaction between implanted device and neural tissue (pdf)

12. Compatibility issues in multimodal neuroimaging applications (pdf)


Compulsory: handout of the lectures (available through the above download links).


K.D. Wise et al, Microelectrodes, Microelectronics, and Implantable Neural Microsystems, Proceedings of the IEEE 96 (2008) 1184-1202

Z. Fekete et al., Multifunctional soft implants to monitor and control neural activity in the central and peripheral nervous system: a review, Sensors & Actuators B-Chemical 243 (2017) 1214-1223

Z. Fekete, Recent advances in silicon-based neural microelectrodes and microsystems: a review, Sensors & Actuators B-Chemical 215 (2015) 300-315